- Title
- Triple Surfactant Assisted Synthesis of Novel Core-Shell Mesoporous Silica Nanoparticles with High Surface Area for Drug Delivery for Prostate Cancer
- Creator
- Tiburcius, Steffi; Krishnan, Kannan; Patel, Vaishwik; Netherton, Jacob; Sathish, C. I.; Weidenhofer, Judith; Yang, Jae-Hun; Verrills, Nicole M.; Karakoti, Ajay; Vinu, Ajayan
- Relation
- Bulletin of the Chemical Society of Japan Vol. 95, Issue 2, p. 331-340
- Publisher Link
- http://dx.doi.org/10.1246/bcsj.20210428
- Publisher
- Chemical Society of Japan,Nippon Kagakukai
- Resource Type
- journal article
- Date
- 2022
- Description
- Core-shell mesoporous silica nanoparticles (MSN) have recently emerged as a promising drug delivery system that can be used for loading large quantities of different types of drugs or creating a stimuli responsive system. However, achieving this unique core-shell morphology with smaller size, high specific surface area, and large pore volume is highly challenging. In this study, we report the synthesis of core-shell MSN using a triple surfactant assisted soft-templating approach. We show that the size, morphological and textural properties of the core-shell structures can be easily modified by controlling the amount of fluorocarbon-4 surfactant. The optimised core shell MSN showed the highest surface area of 1496 m2/g that helped in achieving a high drug loading of model drugs doxorubicin (34%) or docetaxel (50%). The small size of core-shell MSN facilitated its rapid uptake within the PC-3 cells within 12 h. The cytotoxicity data using drug loaded MSN showed high cytotoxicity in both PC-3 and LNCaP cell lines suggesting that this versatile platform is efficient in delivering different drugs to various cell types. This unique triple surfactant assisted synthesis of core-shell MSN will open the door for multifaceted applications in imaging and drug delivery.
- Subject
- mesoporous; drug delivery; prostate cancer; surface area; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1469359
- Identifier
- uon:48220
- Identifier
- ISSN:0009-2673
- Language
- eng
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